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PC Cleaner Pro 9.3.0.5 instal the new4/12/2024 ![]() ![]() The mitochondrial dysfunctions provoked by defects in mitochondrial DNA maintenance provoke severe diseases in humans (9) and in mice (10). Dynamics ensure the distribution and exchange of mitochondrial DNA, which is organized in hundreds of punctate nucleoids that distribute throughout mitochondria (2,8). Herrmann © Humana Press Inc., Totowa, NJĪre responsible for severe human diseases (5,6), and their knockout hampers development of viable mice (7), demonstrating the relevance of mitochondrial dynamics for the development and function of entire organisms. 372: Mitochondria: Practical Protocols Edited by: D. Mutations in genes encoding such proteins From: Methods in Molecular Biology, vol. Mitochondrial dynamics are governed by specific proteins, a majority of which have been described and characterized in the recent past (3,4). Mitochondria represent a single cellular compartment where deoxyribonucleic acid (DNA) and proteins are exchanged through continuous fusion and fission reactions (1,2). Introduction Mitochondria are involved in numerous essential cellular processes: they produce adenosine triphosphate (ATP) by oxidative phosphorylation, participate in various metabolic pathways, contribute to calcium homeostasis and signaling, and play a key role in apoptosis. Key Words: Cytochrome-c oxidase mitochondrial fusion mitochondrial morphology succinate dehydrogenase.ġ. In this chapter, we describe methods for the visualization of mitochondria and mitochondrial activity in cultured mammalian cells to establish the localization or distribution of its components and to study mitochondrial fusion. ![]() ![]() The recent past has seen the identification and characterization of the first proteins governing the organization, function, and dynamics of mitochondria and mitochondrial DNA, and it is predictable that numerous new proteins will require localization and functional characterization in the future. Spelbrink, and Manuel Rojo Summary Mitochondria form a dynamic network in which continuous movement, fusion, and division ensure the distribution and exchange of proteins and deoxyribonucleic acid (DNA). 1 The Mitochondria of Cultured Mammalian Cells I: Analysis by Immunofluorescence Microscopy, Histochemistry, Subcellular Fractionation, and Cell Fusion Florence Malka, Karine Auré, Steffi Goffart, Johannes N. ![]()
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